Motorists have been told to find alternative routes as the investigation gets underway.
“Police officers are at the scene, however the road is likely to be closed until late morning.”
There is no access through the scene from either direction from the Blue Elephant to Ackurst Lane including Gathurst train station, according to traffic police.
Police remain on the scene at Gathurst Road in Wigan following the early morning crash.
Greater Manchester Police said: “Please note that Gathurst Road is currently closed between Gathurst Bridge and Gathurst Station due to a serious road traffic collision.
More to follow…
The road is closed in both directions between Gathurst Bridge and Gathurst Station.