A medication that eases the results of jetlag may help prevent painful side-effects from cancer medicines, new information finds.
The research in rats, printed within the Journal of Pineal Research, demonstrated the drug – referred to as melatonin – blocked dangerous results of chemotherapy on nerve health.
“These answers are promising, especially as melatonin treatment is proven to be safe in other concerns,Inches stated co-lead investigator Helen Galley, Professor at Institute of Medical Sciences in the College of Aberdeen in Scotland.
“However, more work will have to be done before we all know if melatonin can help prevent discomfort in cancer patients undergoing chemotherapy,” Galley added.
The scientists centered on a typical condition referred to as chemotherapy-caused neuropathic discomfort (CINP), which in turn causes tingling and discomfort sensation to the touch and cold conditions that may be severe enough to result in patients to limit their chemotherapy treatment.
The research demonstrated that melatonin given just before chemotherapy limited the harmful impact on nerve cells and the introduction of discomfort signs and symptoms.
Within this study, melatonin didn’t alleviate discomfort when CINP had already developed, suggesting that it is potential benefits may be as prevention instead of cure.
Importantly, melatonin treatment didn’t hinder the advantageous anti-cancer results of chemotherapy in human breast and ovarian cancer cells.
Findings also demonstrated that melatonin reduced damage brought on by chemotherapy to vital areas of nerve cells referred to as mitochondria.
Experts say reducing injury to these cell energy centres could contain the answer to stopping chemotherapy-caused neuropathic discomfort which affects almost 70% of patients undergoing chemotherapy and may have severe effect on quality of existence.
Everyday activity, including fastening buttons or walking barefoot, may cause discomfort that may persist despite cancer is cured, and therefore some people are not able to go back to work or able to handle household tasks.
“We are positively exploring an earlier-phase clinical study to find out if these exciting laboratory findings might mean direct benefit for patients undergoing chemotherapy. It is really an section of real unmet need, where new therapies are urgently needed,” Lesley Colvin, Professor at College of Edinburgh, stated. – IANS

Leave a Comment

Your email address will not be published. Required fields are marked *