The AstraZeneca vaccine began to be accepted in Indonesia in March 2021. The AstraZeneca vaccine had reaped pros and cons in the community, because in the manufacturing process it contains trypsin derived from pig enzymes. Based on the MUI explanation, the AstraZeneca vaccine was declared haram, but it was allowed to be used. MUI allows its use, one of the reasons is because Indonesia is experiencing a health emergency so it urgently needs the COVID-19 vaccine. Coupled with the insufficient availability of halal vaccines in Indonesia and globally. From some media that I read also mentioned, Sinovac vaccine will soon reach expiration. Although the MUI declared the AstraZeneca vaccine haram, it turned out that this vaccine had already been approved for use in more than 70 countries in the world, including Islamic countries.